منابع مشابه
Neuropeptide GPCRs in Neuroendocrinology
G protein-coupled receptors (GPCRs) represent the single largest family of plasma membrane receptors, encompassing about 860 members in humans. During the last decades, considerable progress has been made regarding the biochemical identification, signaling mechanisms, allosteric modulation, structural characterization, and pathophysiological implication of GPCRs, which are considered as major t...
متن کاملNeuropeptide GPCRs in neuroendocrinology: the case of activity-dependent neuroprotective protein (ADNP)
VASOACTIVE INTESTINAL PEPTIDE (VIP): NEUROPROTECTION AND SYNAPSE FORMATION This review is a selected overview of the chosen subject. As, I have recently summarized my work on VIP (Gozes, 2008), I will describe here only selected topics focusing on the GPCR connection of the VIP-regulated protein, activity-dependent neuroprotective protein (ADNP) (Gozes, 2007). In the mid 1980s we were the first...
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Like most organisms, the nematode Caenorhabditis elegans relies heavily on neuropeptidergic signaling. This tiny animal represents a suitable model system to study neuropeptidergic signaling networks with single cell resolution due to the availability of powerful molecular and genetic tools. The availability of the worm's complete genome sequence allows researchers to browse through it, uncover...
متن کاملLarge-Scale Combinatorial Deorphanization of Platynereis Neuropeptide GPCRs.
Neuropeptides, representing the largest class of neuromodulators, commonly signal by G-protein-coupled receptors (GPCRs). While the neuropeptide repertoire of several metazoans has been characterized, many GPCRs are orphans. Here, we develop a strategy to identify GPCR-peptide pairs using combinatorial screening with complex peptide mixtures. We screened 126 neuropeptides against 87 GPCRs of th...
متن کاملMore than two decades of research on insect neuropeptide GPCRs: an overview
This review focuses on the state of the art on neuropeptide receptors in insects. Most of these receptors are G protein-coupled receptors (GPCRs) and are involved in the regulation of virtually all physiological processes during an insect's life. More than 20 years ago a milestone in invertebrate endocrinology was achieved with the characterization of the first insect neuropeptide receptor, i.e...
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ژورنال
عنوان ژورنال: Frontiers in Endocrinology
سال: 2014
ISSN: 1664-2392
DOI: 10.3389/fendo.2014.00041